Harold Lee and Kumar Patel are best friends and roommates who share a common love for marijuana. Harold works for an investment bank while Kumar is being pressured by his father to go into medical school. On a Friday night after smoking marijuana, the duo get a case of the munchies and decide to head to White Castle. However, after learning that the nearest White Castle has been closed down, the duo set out on a trip to a White Castle that is not too far out. However, the trip becomes complicated as the duo run into one incident after another.