When disc jockey Grant Mazzy reports to his basement radio station in the Canadian town of Pontypool, he thinks it's just another day at work. But when he hears reports of a virus that turns people into zombies, Mazzy barricades himself in the radio booth and tries to figure out a way to warn his listeners about the virus and its unlikely mode of transmission.
In the small town of Pontypool, Ontario, former shock jock turned radio announcer Grant Mazzy drives through a blizzard on his way to work. When poor visibility forces him to stop his car, an underdressed woman appears on the road, startling him. Grant calls out to her, but she disappears into the storm, ominously repeating his words and visibly disturbing him. Grant eventually arrives at the radio station, where he works with technical assistant Laurel-Ann Drummond and station manager Sydney Briar...