The FBI's top profiler John Hartley (Dwayne Johnson) is on the case when an Interpol-issued Red Notice, the highest level warrant to hunt down and apprehend the world's most wanted, is issued. His global search lands him in the center of a daring theft, forcing him to team up with Nolan Booth (Ryan Reynolds), the world's finest art thief, in order to apprehend "The Bishop," the world's most sought art thief (Gal Gadot). The ensuing high-flying journey takes the trio all over the world, across the dance floor, into an isolated prison, into the forest, and, worst of all, into each other's presence.