Sean Jones was riding a motorcycle in Hawaii and witnessed the brutal murder of a prosecutor. When the villain came to kill Sean, agent Neville Flynn (Neville Flynn) came to his rescue. To protect Sean's trip back to Los Angeles, Flynn took over entire first class portion of Pacific Airlines Flight 121. Disgruntled first-class passengers aside, the flight was uneventful until hundreds of angry poisonous snakes were released into the cabin. Once the snake started attacking, Agents Flynn and Sean needed to keep the plane in the air and rescue as many passengers as possible.