In 1974, in the Glenville Sanatorium in West Virginia, three dangerous lunatics escape from their cell, release the other inmates and kill the doctors and staff. In 2003, a group of college friends from the Weston University rides their snowmobiles to the cabin of a friend. However, they get lost in a storm and reach the abandoned asylum seeking for shelter to spend the night. However, the three cannibal maniacs are still living in the place and they are hungry for human flesh.