El Juego de las Llaves is a half-hour drama-comedy based on the lives of millions of couples that struggle with infidelity due to long-term monogamy, self-fulfillment, and desire. The show follows four couples, all in solid marriages, as they go on a game of sexual discovery by trading spouses in order to break free from their daily routines and spice up their relationships. The game takes on a life of its own as each couple explores their own secret desires, and the couples must confront the consequences of their choices and attitudes on sexuality.